Retatrutide half-life
Retatrutide has an elimination half-life of about 6 days (range 5.6–6.9 days). Use the free calculator to plot how Retatrutide levels rise and decay across your own doses.
Open Retatrutide in the calculator
Reference data
- Half-life
- 6 days (range 5.6–6.9 days)
- Route
- SC weekly
- Category
- GLP-1 & incretins
- Evidence
- Limited
- Also known as
- LY3437943
Phase 1/2 trials: about 6 days.
How much Retatrutide remains over time
For a single dose with first-order elimination, half of what remains is cleared every 6 days.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 6 days | 50% | 50% |
| 2 | 12 days | 25% | 75% |
| 3 | 18 days | 12.5% | 87.5% |
| 4 | 24 days | 6.25% | 93.75% |
| 5 | 30 days | 3.13% | 96.88% |
Retatrutide FAQ
What is the half-life of Retatrutide?
Retatrutide has an elimination half-life of about 6 days (range 5.6–6.9 days) (SC weekly). Phase 1/2 trials: about 6 days.
How long does Retatrutide stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 30 days for Retatrutide. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Retatrutide reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 24 days to 30 days for Retatrutide.
How reliable is this Retatrutide half-life?
Evidence level: Limited. Based on early-phase human trials, small human studies, or animal pharmacokinetics only.