Lixisenatide half-life
Lixisenatide has an elimination half-life of about 3 h. Use the free calculator to plot how Lixisenatide levels rise and decay across your own doses.
Open Lixisenatide in the calculator
Reference data
- Half-life
- 3 h
- Route
- SC daily
- Category
- GLP-1 & incretins
- Evidence
- Clinical
- Also known as
- Adlyxin, Lyxumia
Label: about 3 hours.
How much Lixisenatide remains over time
For a single dose with first-order elimination, half of what remains is cleared every 3 h.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 3 h | 50% | 50% |
| 2 | 6 h | 25% | 75% |
| 3 | 9 h | 12.5% | 87.5% |
| 4 | 12 h | 6.25% | 93.75% |
| 5 | 15 h | 3.13% | 96.88% |
Lixisenatide FAQ
What is the half-life of Lixisenatide?
Lixisenatide has an elimination half-life of about 3 h (SC daily). Label: about 3 hours.
How long does Lixisenatide stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 15 h for Lixisenatide. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Lixisenatide reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 12 h to 15 h for Lixisenatide.
How reliable is this Lixisenatide half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.