Exenatide half-life
Exenatide has an elimination half-life of about 2.4 h. Use the free calculator to plot how Exenatide levels rise and decay across your own doses.
Open Exenatide in the calculator
Reference data
- Half-life
- 2.4 h
- Route
- SC twice daily
- Category
- GLP-1 & incretins
- Evidence
- Clinical
- Also known as
- Byetta
Immediate-release label value. Extended-release (Bydureon) is absorption-limited.
How much Exenatide remains over time
For a single dose with first-order elimination, half of what remains is cleared every 2.4 h.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 2.4 h | 50% | 50% |
| 2 | 4.8 h | 25% | 75% |
| 3 | 7.2 h | 12.5% | 87.5% |
| 4 | 9.6 h | 6.25% | 93.75% |
| 5 | 12 h | 3.13% | 96.88% |
Exenatide FAQ
What is the half-life of Exenatide?
Exenatide has an elimination half-life of about 2.4 h (SC twice daily). Immediate-release label value. Extended-release (Bydureon) is absorption-limited.
How long does Exenatide stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 12 h for Exenatide. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Exenatide reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 9.6 h to 12 h for Exenatide.
How reliable is this Exenatide half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.