Semaglutide half-life
Semaglutide has an elimination half-life of about 6.9 days (range 6–7 days). Use the free calculator to plot how Semaglutide levels rise and decay across your own doses.
Open Semaglutide in the calculator
Reference data
- Half-life
- 6.9 days (range 6–7 days)
- Route
- SC weekly / oral daily
- Category
- GLP-1 & incretins
- Evidence
- Clinical
- Also known as
- Ozempic, Wegovy, Rybelsus
FDA label: elimination half-life of about 1 week.
How much Semaglutide remains over time
For a single dose with first-order elimination, half of what remains is cleared every 6.9 days.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 6.9 days | 50% | 50% |
| 2 | 13.8 days | 25% | 75% |
| 3 | 20.6 days | 12.5% | 87.5% |
| 4 | 27.5 days | 6.25% | 93.75% |
| 5 | 34.4 days | 3.13% | 96.88% |
Semaglutide FAQ
What is the half-life of Semaglutide?
Semaglutide has an elimination half-life of about 6.9 days (range 6–7 days) (SC weekly / oral daily). FDA label: elimination half-life of about 1 week.
How long does Semaglutide stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 34.4 days for Semaglutide. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Semaglutide reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 27.5 days to 34.4 days for Semaglutide.
How reliable is this Semaglutide half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.