Tirzepatide half-life
Tirzepatide has an elimination half-life of about 5 days. Use the free calculator to plot how Tirzepatide levels rise and decay across your own doses.
Open Tirzepatide in the calculator
Reference data
- Half-life
- 5 days
- Route
- SC weekly
- Category
- GLP-1 & incretins
- Evidence
- Clinical
- Also known as
- Mounjaro, Zepbound
FDA label: half-life of about 5 days.
How much Tirzepatide remains over time
For a single dose with first-order elimination, half of what remains is cleared every 5 days.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 5 days | 50% | 50% |
| 2 | 10 days | 25% | 75% |
| 3 | 15 days | 12.5% | 87.5% |
| 4 | 20 days | 6.25% | 93.75% |
| 5 | 25 days | 3.13% | 96.88% |
Tirzepatide FAQ
What is the half-life of Tirzepatide?
Tirzepatide has an elimination half-life of about 5 days (SC weekly). FDA label: half-life of about 5 days.
How long does Tirzepatide stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 25 days for Tirzepatide. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Tirzepatide reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 20 days to 25 days for Tirzepatide.
How reliable is this Tirzepatide half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.