Cagrilintide half-life
Cagrilintide has an elimination half-life of about 7.3 days (range 6.6–8.1 days). Use the free calculator to plot how Cagrilintide levels rise and decay across your own doses.
Open Cagrilintide in the calculator
Reference data
- Half-life
- 7.3 days (range 6.6–8.1 days)
- Route
- SC weekly
- Category
- GLP-1 & incretins
- Evidence
- Limited
- Also known as
- NN9838
Phase 1b (with semaglutide): 159–195 hours.
How much Cagrilintide remains over time
For a single dose with first-order elimination, half of what remains is cleared every 7.3 days.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 7.3 days | 50% | 50% |
| 2 | 14.6 days | 25% | 75% |
| 3 | 21.9 days | 12.5% | 87.5% |
| 4 | 29.2 days | 6.25% | 93.75% |
| 5 | 36.5 days | 3.13% | 96.88% |
Cagrilintide FAQ
What is the half-life of Cagrilintide?
Cagrilintide has an elimination half-life of about 7.3 days (range 6.6–8.1 days) (SC weekly). Phase 1b (with semaglutide): 159–195 hours.
How long does Cagrilintide stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 36.5 days for Cagrilintide. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Cagrilintide reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 29.2 days to 36.5 days for Cagrilintide.
How reliable is this Cagrilintide half-life?
Evidence level: Limited. Based on early-phase human trials, small human studies, or animal pharmacokinetics only.