Pramlintide half-life
Pramlintide has an elimination half-life of about 48 min. Use the free calculator to plot how Pramlintide levels rise and decay across your own doses.
Open Pramlintide in the calculator
Reference data
- Half-life
- 48 min
- Route
- SC with meals
- Category
- GLP-1 & incretins
- Evidence
- Clinical
- Also known as
- Symlin
FDA label: about 48 minutes.
How much Pramlintide remains over time
For a single dose with first-order elimination, half of what remains is cleared every 48 min.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 48 min | 50% | 50% |
| 2 | 1.6 h | 25% | 75% |
| 3 | 2.4 h | 12.5% | 87.5% |
| 4 | 3.2 h | 6.25% | 93.75% |
| 5 | 4 h | 3.13% | 96.88% |
Pramlintide FAQ
What is the half-life of Pramlintide?
Pramlintide has an elimination half-life of about 48 min (SC with meals). FDA label: about 48 minutes.
How long does Pramlintide stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 4 h for Pramlintide. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Pramlintide reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 3.2 h to 4 h for Pramlintide.
How reliable is this Pramlintide half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.