Retatrutide vs Mazdutide half-life
Retatrutide has an elimination half-life of about 6 days; Mazdutide has about 8 days. Both are investigational multi-receptor agonists. Retatrutide targets GIP, GLP-1 and glucagon receptors, while mazdutide is a GLP-1/glucagon dual agonist. Both have half-lives that support weekly dosing.
Side by side
| Retatrutide | Mazdutide | |
|---|---|---|
| Half-life | 6 days (range 5.6–6.9 days) | 8 days (range 7.3–10.8 days) |
| Route | SC weekly | SC weekly |
| Category | GLP-1 & incretins | GLP-1 & incretins |
| Evidence | Limited | Limited |
| Remaining after 24 hours | 89.1% | 91.7% |
| Remaining after 7 days | 44.5% | 54.5% |
| ~97% cleared (5 half-lives) | 30 days | 40 days |
| Steady state (4-5 half-lives) | 24 days to 30 days | 32 days to 40 days |
Single-dose decay
Share of one dose remaining over time, assuming first-order elimination. Dashed lines mark each half-life.
Retatrutide (t½ 6 days) Mazdutide (t½ 8 days)
Retatrutide: Phase 1/2 trials: about 6 days. Mazdutide: Phase 1: about 8 days at 16 mg; early cohorts were highly variable.
FAQ
Which lasts longer, Retatrutide or Mazdutide?
Mazdutide lasts longer. Its half-life is about 8 days, versus 6 days for Retatrutide, roughly 1.3 times longer.
How long do Retatrutide and Mazdutide stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives: roughly 30 days for Retatrutide and 40 days for Mazdutide. Individual clearance varies.
How long until Retatrutide and Mazdutide reach steady state?
With consistent repeated dosing, levels approach steady state after 4 to 5 half-lives: about 24 days to 30 days for Retatrutide, and 32 days to 40 days for Mazdutide.
How reliable are these half-lives?
Retatrutide: Limited evidence. Mazdutide: Limited evidence. Anecdotal values are community estimates and may be far off.