Mazdutide half-life
Mazdutide has an elimination half-life of about 8 days (range 7.3–10.8 days). Use the free calculator to plot how Mazdutide levels rise and decay across your own doses.
Open Mazdutide in the calculator
Reference data
- Half-life
- 8 days (range 7.3–10.8 days)
- Route
- SC weekly
- Category
- GLP-1 & incretins
- Evidence
- Limited
- Also known as
- IBI362, LY3305677
Phase 1: about 8 days at 16 mg; early cohorts were highly variable.
How much Mazdutide remains over time
For a single dose with first-order elimination, half of what remains is cleared every 8 days.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 8 days | 50% | 50% |
| 2 | 16 days | 25% | 75% |
| 3 | 24 days | 12.5% | 87.5% |
| 4 | 32 days | 6.25% | 93.75% |
| 5 | 40 days | 3.13% | 96.88% |
Mazdutide FAQ
What is the half-life of Mazdutide?
Mazdutide has an elimination half-life of about 8 days (range 7.3–10.8 days) (SC weekly). Phase 1: about 8 days at 16 mg; early cohorts were highly variable.
How long does Mazdutide stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 40 days for Mazdutide. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Mazdutide reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 32 days to 40 days for Mazdutide.
How reliable is this Mazdutide half-life?
Evidence level: Limited. Based on early-phase human trials, small human studies, or animal pharmacokinetics only.