Survodutide half-life
Survodutide has an elimination half-life of about 5 days (range 4.5–5.4 days). Use the free calculator to plot how Survodutide levels rise and decay across your own doses.
Open Survodutide in the calculator
Reference data
- Half-life
- 5 days (range 4.5–5.4 days)
- Route
- SC weekly
- Category
- GLP-1 & incretins
- Evidence
- Limited
- Also known as
- BI 456906
Phase 1: terminal half-life about 109–130 hours.
How much Survodutide remains over time
For a single dose with first-order elimination, half of what remains is cleared every 5 days.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 5 days | 50% | 50% |
| 2 | 10 days | 25% | 75% |
| 3 | 15 days | 12.5% | 87.5% |
| 4 | 20 days | 6.25% | 93.75% |
| 5 | 25 days | 3.13% | 96.88% |
Survodutide FAQ
What is the half-life of Survodutide?
Survodutide has an elimination half-life of about 5 days (range 4.5–5.4 days) (SC weekly). Phase 1: terminal half-life about 109–130 hours.
How long does Survodutide stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 25 days for Survodutide. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Survodutide reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 20 days to 25 days for Survodutide.
How reliable is this Survodutide half-life?
Evidence level: Limited. Based on early-phase human trials, small human studies, or animal pharmacokinetics only.