Metreleptin half-life
Metreleptin has an elimination half-life of about 4.3 h (range 3.8–4.7 h). Use the free calculator to plot how Metreleptin levels rise and decay across your own doses.
Open Metreleptin in the calculator
Reference data
- Half-life
- 4.3 h (range 3.8–4.7 h)
- Route
- SC daily
- Category
- Metabolic & endocrine
- Evidence
- Clinical
- Also known as
- Myalept, Leptin
FDA label: 3.8–4.7 hours.
How much Metreleptin remains over time
For a single dose with first-order elimination, half of what remains is cleared every 4.3 h.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 4.3 h | 50% | 50% |
| 2 | 8.6 h | 25% | 75% |
| 3 | 12.9 h | 12.5% | 87.5% |
| 4 | 17.2 h | 6.25% | 93.75% |
| 5 | 21.5 h | 3.13% | 96.88% |
Metreleptin FAQ
What is the half-life of Metreleptin?
Metreleptin has an elimination half-life of about 4.3 h (range 3.8–4.7 h) (SC daily). FDA label: 3.8–4.7 hours.
How long does Metreleptin stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 21.5 h for Metreleptin. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Metreleptin reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 17.2 h to 21.5 h for Metreleptin.
How reliable is this Metreleptin half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.