Insulin lispro half-life
Insulin lispro has an elimination half-life of about 1 h. Use the free calculator to plot how Insulin lispro levels rise and decay across your own doses.
Open Insulin lispro in the calculator
Reference data
- Half-life
- 1 h
- Route
- SC
- Category
- Insulins
- Evidence
- Clinical
- Also known as
- Humalog, Admelog, Lyumjev
Apparent SC half-life of about 1 hour.
How much Insulin lispro remains over time
For a single dose with first-order elimination, half of what remains is cleared every 1 h.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 1 h | 50% | 50% |
| 2 | 2 h | 25% | 75% |
| 3 | 3 h | 12.5% | 87.5% |
| 4 | 4 h | 6.25% | 93.75% |
| 5 | 5 h | 3.13% | 96.88% |
Insulin lispro FAQ
What is the half-life of Insulin lispro?
Insulin lispro has an elimination half-life of about 1 h (SC). Apparent SC half-life of about 1 hour.
How long does Insulin lispro stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 5 h for Insulin lispro. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Insulin lispro reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 4 h to 5 h for Insulin lispro.
How reliable is this Insulin lispro half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.