Regular human insulin half-life
Regular human insulin has an elimination half-life of about 1.5 h. Use the free calculator to plot how Regular human insulin levels rise and decay across your own doses.
Open Regular human insulin in the calculator
Reference data
- Half-life
- 1.5 h
- Route
- SC
- Category
- Insulins
- Evidence
- Clinical
- Also known as
- Humulin R, Novolin R, Insulin regular
Apparent SC half-life of about 1.5 hours.
How much Regular human insulin remains over time
For a single dose with first-order elimination, half of what remains is cleared every 1.5 h.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 1.5 h | 50% | 50% |
| 2 | 3 h | 25% | 75% |
| 3 | 4.5 h | 12.5% | 87.5% |
| 4 | 6 h | 6.25% | 93.75% |
| 5 | 7.5 h | 3.13% | 96.88% |
Regular human insulin FAQ
What is the half-life of Regular human insulin?
Regular human insulin has an elimination half-life of about 1.5 h (SC). Apparent SC half-life of about 1.5 hours.
How long does Regular human insulin stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 7.5 h for Regular human insulin. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Regular human insulin reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 6 h to 7.5 h for Regular human insulin.
How reliable is this Regular human insulin half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.