Insulin degludec half-life
Insulin degludec has an elimination half-life of about 25 h. Use the free calculator to plot how Insulin degludec levels rise and decay across your own doses.
Open Insulin degludec in the calculator
Reference data
- Half-life
- 25 h
- Route
- SC daily
- Category
- Insulins
- Evidence
- Clinical
- Also known as
- Tresiba
FDA label: about 25 hours.
How much Insulin degludec remains over time
For a single dose with first-order elimination, half of what remains is cleared every 25 h.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 25 h | 50% | 50% |
| 2 | 2.1 days | 25% | 75% |
| 3 | 3.1 days | 12.5% | 87.5% |
| 4 | 4.2 days | 6.25% | 93.75% |
| 5 | 5.2 days | 3.13% | 96.88% |
Insulin degludec FAQ
What is the half-life of Insulin degludec?
Insulin degludec has an elimination half-life of about 25 h (SC daily). FDA label: about 25 hours.
How long does Insulin degludec stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 5.2 days for Insulin degludec. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Insulin degludec reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 4.2 days to 5.2 days for Insulin degludec.
How reliable is this Insulin degludec half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.