Insulin lispro vs Insulin aspart half-life
Insulin lispro has an elimination half-life of about 1 h; Insulin aspart has about 1.4 h. Both are rapid-acting mealtime insulin analogues with small amino-acid changes that speed absorption. Their pharmacokinetics are very similar.
Side by side
| Insulin lispro | Insulin aspart | |
|---|---|---|
| Half-life | 1 h | 1.4 h |
| Route | SC | SC |
| Category | Insulins | Insulins |
| Evidence | Clinical | Clinical |
| Remaining after 24 hours | <0.01% | <0.01% |
| Remaining after 7 days | <0.01% | <0.01% |
| ~97% cleared (5 half-lives) | 5 h | 6.8 h |
| Steady state (4-5 half-lives) | 4 h to 5 h | 5.4 h to 6.8 h |
Single-dose decay
Share of one dose remaining over time, assuming first-order elimination. Dashed lines mark each half-life.
Insulin lispro (t½ 1 h) Insulin aspart (t½ 1.4 h)
Insulin lispro: Apparent SC half-life of about 1 hour. Insulin aspart: Label: about 81 minutes.
FAQ
Which lasts longer, Insulin lispro or Insulin aspart?
Insulin aspart lasts longer. Its half-life is about 1.4 h, versus 1 h for Insulin lispro, roughly 1.4 times longer.
How long do Insulin lispro and Insulin aspart stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives: roughly 5 h for Insulin lispro and 6.8 h for Insulin aspart. Individual clearance varies.
How long until Insulin lispro and Insulin aspart reach steady state?
With consistent repeated dosing, levels approach steady state after 4 to 5 half-lives: about 4 h to 5 h for Insulin lispro, and 5.4 h to 6.8 h for Insulin aspart.
How reliable are these half-lives?
Insulin lispro: Clinical evidence. Insulin aspart: Clinical evidence. Anecdotal values are community estimates and may be far off.