Ipamorelin vs Sermorelin half-life
Ipamorelin has an elimination half-life of about 2 h; Sermorelin has about 12 min. Sermorelin is a GHRH analogue (the first 29 amino acids of GHRH), while ipamorelin is a selective ghrelin-receptor agonist. They stimulate growth hormone release through different receptors.
Side by side
| Ipamorelin | Sermorelin | |
|---|---|---|
| Half-life | 2 h | 12 min (range 10–20 min) |
| Route | SC / IV | SC |
| Category | GH secretagogues | GH secretagogues |
| Evidence | Limited | Clinical |
| Remaining after 24 hours | 0.02% | <0.01% |
| Remaining after 7 days | <0.01% | <0.01% |
| ~97% cleared (5 half-lives) | 10 h | 1 h |
| Steady state (4-5 half-lives) | 8 h to 10 h | 48 min to 1 h |
Single-dose decay
Share of one dose remaining over time, assuming first-order elimination. Dashed lines mark each half-life.
Ipamorelin (t½ 2 h) Sermorelin (t½ 12 min)
Ipamorelin: Human IV PK study: terminal half-life about 2 hours. Sermorelin: Former label: about 11–12 minutes.
FAQ
Which lasts longer, Ipamorelin or Sermorelin?
Ipamorelin lasts longer. Its half-life is about 2 h, versus 12 min for Sermorelin, roughly 10 times longer.
How long do Ipamorelin and Sermorelin stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives: roughly 10 h for Ipamorelin and 1 h for Sermorelin. Individual clearance varies.
How long until Ipamorelin and Sermorelin reach steady state?
With consistent repeated dosing, levels approach steady state after 4 to 5 half-lives: about 8 h to 10 h for Ipamorelin, and 48 min to 1 h for Sermorelin.
How reliable are these half-lives?
Ipamorelin: Limited evidence. Sermorelin: Clinical evidence. Anecdotal values are community estimates and may be far off.