Ipamorelin vs GHRP-6 half-life
Ipamorelin has an elimination half-life of about 2 h; GHRP-6 has about 30 min. Both are ghrelin-receptor agonists. GHRP-6 is an older peptide known for strongly increasing appetite, while ipamorelin is more selective for growth hormone release.
Side by side
| Ipamorelin | GHRP-6 | |
|---|---|---|
| Half-life | 2 h | 30 min (range 15 min–1 h) |
| Route | SC / IV | SC |
| Category | GH secretagogues | GH secretagogues |
| Evidence | Limited | Limited |
| Remaining after 24 hours | 0.02% | <0.01% |
| Remaining after 7 days | <0.01% | <0.01% |
| ~97% cleared (5 half-lives) | 10 h | 2.5 h |
| Steady state (4-5 half-lives) | 8 h to 10 h | 2 h to 2.5 h |
Single-dose decay
Share of one dose remaining over time, assuming first-order elimination. Dashed lines mark each half-life.
Ipamorelin (t½ 2 h) GHRP-6 (t½ 30 min)
Ipamorelin: Human IV PK study: terminal half-life about 2 hours. GHRP-6: Sparse human PK; short plasma half-life.
FAQ
Which lasts longer, Ipamorelin or GHRP-6?
Ipamorelin lasts longer. Its half-life is about 2 h, versus 30 min for GHRP-6, roughly 4 times longer.
How long do Ipamorelin and GHRP-6 stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives: roughly 10 h for Ipamorelin and 2.5 h for GHRP-6. Individual clearance varies.
How long until Ipamorelin and GHRP-6 reach steady state?
With consistent repeated dosing, levels approach steady state after 4 to 5 half-lives: about 8 h to 10 h for Ipamorelin, and 2 h to 2.5 h for GHRP-6.
How reliable are these half-lives?
Ipamorelin: Limited evidence. GHRP-6: Limited evidence. Anecdotal values are community estimates and may be far off.