Ipamorelin vs CJC-1295 (no DAC) half-life
Ipamorelin has an elimination half-life of about 2 h; CJC-1295 (no DAC) has about 30 min. CJC-1295 without DAC (Mod GRF 1-29) is a GHRH analogue, while ipamorelin acts on the ghrelin receptor. Because they work through different pathways, they are often researched together.
Side by side
| Ipamorelin | CJC-1295 (no DAC) | |
|---|---|---|
| Half-life | 2 h | 30 min |
| Route | SC / IV | SC |
| Category | GH secretagogues | GH secretagogues |
| Evidence | Limited | Anecdotal |
| Remaining after 24 hours | 0.02% | <0.01% |
| Remaining after 7 days | <0.01% | <0.01% |
| ~97% cleared (5 half-lives) | 10 h | 2.5 h |
| Steady state (4-5 half-lives) | 8 h to 10 h | 2 h to 2.5 h |
Single-dose decay
Share of one dose remaining over time, assuming first-order elimination. Dashed lines mark each half-life.
Ipamorelin (t½ 2 h) CJC-1295 (no DAC) (t½ 30 min)
Ipamorelin: Human IV PK study: terminal half-life about 2 hours. CJC-1295 (no DAC): No formal human PK; commonly estimated at about 30 minutes.
FAQ
Which lasts longer, Ipamorelin or CJC-1295 (no DAC)?
Ipamorelin lasts longer. Its half-life is about 2 h, versus 30 min for CJC-1295 (no DAC), roughly 4 times longer.
How long do Ipamorelin and CJC-1295 (no DAC) stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives: roughly 10 h for Ipamorelin and 2.5 h for CJC-1295 (no DAC). Individual clearance varies.
How long until Ipamorelin and CJC-1295 (no DAC) reach steady state?
With consistent repeated dosing, levels approach steady state after 4 to 5 half-lives: about 8 h to 10 h for Ipamorelin, and 2 h to 2.5 h for CJC-1295 (no DAC).
How reliable are these half-lives?
Ipamorelin: Limited evidence. CJC-1295 (no DAC): Anecdotal evidence. Anecdotal values are community estimates and may be far off.