CJC-1295 with DAC vs CJC-1295 (no DAC) half-life
CJC-1295 with DAC has an elimination half-life of about 7 days; CJC-1295 (no DAC) has about 30 min. The Drug Affinity Complex (DAC) lets CJC-1295 bind albumin in the blood, extending its half-life from about 30 minutes to roughly a week. Without DAC, the peptide acts as a short GHRH pulse.
Side by side
| CJC-1295 with DAC | CJC-1295 (no DAC) | |
|---|---|---|
| Half-life | 7 days (range 5.8–8.1 days) | 30 min |
| Route | SC weekly | SC |
| Category | GH secretagogues | GH secretagogues |
| Evidence | Limited | Anecdotal |
| Remaining after 24 hours | 90.6% | <0.01% |
| Remaining after 7 days | 50% | <0.01% |
| ~97% cleared (5 half-lives) | 35 days | 2.5 h |
| Steady state (4-5 half-lives) | 28 days to 35 days | 2 h to 2.5 h |
Single-dose decay
Share of one dose remaining over time, assuming first-order elimination. Dashed lines mark each half-life.
CJC-1295 with DAC (t½ 7 days) CJC-1295 (no DAC) (t½ 30 min)
At this scale CJC-1295 (no DAC) clears almost immediately. Zoomed in to its first five half-lives:
CJC-1295 with DAC (t½ 7 days) CJC-1295 (no DAC) (t½ 30 min)
CJC-1295 with DAC: Human study (Teichman 2006): 5.8–8.1 days. CJC-1295 (no DAC): No formal human PK; commonly estimated at about 30 minutes.
FAQ
Which lasts longer, CJC-1295 with DAC or CJC-1295 (no DAC)?
CJC-1295 with DAC lasts longer. Its half-life is about 7 days, versus 30 min for CJC-1295 (no DAC), roughly 336 times longer.
How long do CJC-1295 with DAC and CJC-1295 (no DAC) stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives: roughly 35 days for CJC-1295 with DAC and 2.5 h for CJC-1295 (no DAC). Individual clearance varies.
How long until CJC-1295 with DAC and CJC-1295 (no DAC) reach steady state?
With consistent repeated dosing, levels approach steady state after 4 to 5 half-lives: about 28 days to 35 days for CJC-1295 with DAC, and 2 h to 2.5 h for CJC-1295 (no DAC).
How reliable are these half-lives?
CJC-1295 with DAC: Limited evidence. CJC-1295 (no DAC): Anecdotal evidence. Anecdotal values are community estimates and may be far off.