Sermorelin vs Tesamorelin half-life
Sermorelin has an elimination half-life of about 12 min; Tesamorelin has about 30 min. Both are GHRH analogues. Tesamorelin is a stabilized, full-length (44-amino-acid) analogue that is FDA-approved for HIV-associated abdominal fat; sermorelin is a shorter 29-amino-acid fragment.
Side by side
| Sermorelin | Tesamorelin | |
|---|---|---|
| Half-life | 12 min (range 10–20 min) | 30 min (range 26–38 min) |
| Route | SC | SC daily |
| Category | GH secretagogues | GH secretagogues |
| Evidence | Clinical | Clinical |
| Remaining after 24 hours | <0.01% | <0.01% |
| Remaining after 7 days | <0.01% | <0.01% |
| ~97% cleared (5 half-lives) | 1 h | 2.5 h |
| Steady state (4-5 half-lives) | 48 min to 1 h | 2 h to 2.5 h |
Single-dose decay
Share of one dose remaining over time, assuming first-order elimination. Dashed lines mark each half-life.
Sermorelin (t½ 12 min) Tesamorelin (t½ 30 min)
Sermorelin: Former label: about 11–12 minutes. Tesamorelin: FDA label: 26–38 minutes.
FAQ
Which lasts longer, Sermorelin or Tesamorelin?
Tesamorelin lasts longer. Its half-life is about 30 min, versus 12 min for Sermorelin, roughly 2.5 times longer.
How long do Sermorelin and Tesamorelin stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives: roughly 1 h for Sermorelin and 2.5 h for Tesamorelin. Individual clearance varies.
How long until Sermorelin and Tesamorelin reach steady state?
With consistent repeated dosing, levels approach steady state after 4 to 5 half-lives: about 48 min to 1 h for Sermorelin, and 2 h to 2.5 h for Tesamorelin.
How reliable are these half-lives?
Sermorelin: Clinical evidence. Tesamorelin: Clinical evidence. Anecdotal values are community estimates and may be far off.