Somatropin half-life
Somatropin has an elimination half-life of about 3.5 h (range 2–5 h). Use the free calculator to plot how Somatropin levels rise and decay across your own doses.
Open Somatropin in the calculator
Reference data
- Half-life
- 3.5 h (range 2–5 h)
- Route
- SC daily
- Category
- GH & IGF-1
- Evidence
- Clinical
- Also known as
- HGH, Human growth hormone, Genotropin, Norditropin, Humatrope, Omnitrope
Apparent SC half-life of about 2–5 hours (IV is about 20–30 minutes).
How much Somatropin remains over time
For a single dose with first-order elimination, half of what remains is cleared every 3.5 h.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 3.5 h | 50% | 50% |
| 2 | 7 h | 25% | 75% |
| 3 | 10.5 h | 12.5% | 87.5% |
| 4 | 14 h | 6.25% | 93.75% |
| 5 | 17.5 h | 3.13% | 96.88% |
Somatropin FAQ
What is the half-life of Somatropin?
Somatropin has an elimination half-life of about 3.5 h (range 2–5 h) (SC daily). Apparent SC half-life of about 2–5 hours (IV is about 20–30 minutes).
How long does Somatropin stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 17.5 h for Somatropin. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Somatropin reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 14 h to 17.5 h for Somatropin.
How reliable is this Somatropin half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.