Pegvisomant half-life
Pegvisomant has an elimination half-life of about 6 days (range 3.1–7.2 days). Use the free calculator to plot how Pegvisomant levels rise and decay across your own doses.
Open Pegvisomant in the calculator
Reference data
- Half-life
- 6 days (range 3.1–7.2 days)
- Route
- SC daily
- Category
- GH & IGF-1
- Evidence
- Clinical
- Also known as
- Somavert
GH receptor antagonist. Label: about 6 days.
How much Pegvisomant remains over time
For a single dose with first-order elimination, half of what remains is cleared every 6 days.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 6 days | 50% | 50% |
| 2 | 12 days | 25% | 75% |
| 3 | 18 days | 12.5% | 87.5% |
| 4 | 24 days | 6.25% | 93.75% |
| 5 | 30 days | 3.13% | 96.88% |
Pegvisomant FAQ
What is the half-life of Pegvisomant?
Pegvisomant has an elimination half-life of about 6 days (range 3.1–7.2 days) (SC daily). GH receptor antagonist. Label: about 6 days.
How long does Pegvisomant stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 30 days for Pegvisomant. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Pegvisomant reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 24 days to 30 days for Pegvisomant.
How reliable is this Pegvisomant half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.