Mecasermin half-life
Mecasermin has an elimination half-life of about 5.8 h. Use the free calculator to plot how Mecasermin levels rise and decay across your own doses.
Open Mecasermin in the calculator
Reference data
- Half-life
- 5.8 h
- Route
- SC twice daily
- Category
- GH & IGF-1
- Evidence
- Clinical
- Also known as
- Increlex, rhIGF-1, IGF-1
FDA label: about 5.8 hours.
How much Mecasermin remains over time
For a single dose with first-order elimination, half of what remains is cleared every 5.8 h.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 5.8 h | 50% | 50% |
| 2 | 11.6 h | 25% | 75% |
| 3 | 17.4 h | 12.5% | 87.5% |
| 4 | 23.2 h | 6.25% | 93.75% |
| 5 | 29 h | 3.13% | 96.88% |
Mecasermin FAQ
What is the half-life of Mecasermin?
Mecasermin has an elimination half-life of about 5.8 h (SC twice daily). FDA label: about 5.8 hours.
How long does Mecasermin stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 29 h for Mecasermin. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Mecasermin reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 23.2 h to 29 h for Mecasermin.
How reliable is this Mecasermin half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.