Desmopressin half-life
Desmopressin has an elimination half-life of about 2.8 h (range 1.5–3.5 h). Use the free calculator to plot how Desmopressin levels rise and decay across your own doses.
Open Desmopressin in the calculator
Reference data
- Half-life
- 2.8 h (range 1.5–3.5 h)
- Route
- SC / IV / intranasal / oral
- Category
- Reproductive & hormonal
- Evidence
- Clinical
- Also known as
- DDAVP, Noctiva
Label: about 2–3 hours depending on route.
How much Desmopressin remains over time
For a single dose with first-order elimination, half of what remains is cleared every 2.8 h.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 2.8 h | 50% | 50% |
| 2 | 5.6 h | 25% | 75% |
| 3 | 8.4 h | 12.5% | 87.5% |
| 4 | 11.2 h | 6.25% | 93.75% |
| 5 | 14 h | 3.13% | 96.88% |
Desmopressin FAQ
What is the half-life of Desmopressin?
Desmopressin has an elimination half-life of about 2.8 h (range 1.5–3.5 h) (SC / IV / intranasal / oral). Label: about 2–3 hours depending on route.
How long does Desmopressin stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 14 h for Desmopressin. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Desmopressin reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 11.2 h to 14 h for Desmopressin.
How reliable is this Desmopressin half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.