Leuprolide half-life
Leuprolide has an elimination half-life of about 3 h. Use the free calculator to plot how Leuprolide levels rise and decay across your own doses.
Open Leuprolide in the calculator
Reference data
- Half-life
- 3 h
- Route
- SC / IM
- Category
- Reproductive & hormonal
- Evidence
- Clinical
- Also known as
- Leuprorelin, Lupron
Immediate-release: about 3 hours. Depots are release-limited.
How much Leuprolide remains over time
For a single dose with first-order elimination, half of what remains is cleared every 3 h.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 3 h | 50% | 50% |
| 2 | 6 h | 25% | 75% |
| 3 | 9 h | 12.5% | 87.5% |
| 4 | 12 h | 6.25% | 93.75% |
| 5 | 15 h | 3.13% | 96.88% |
Leuprolide FAQ
What is the half-life of Leuprolide?
Leuprolide has an elimination half-life of about 3 h (SC / IM). Immediate-release: about 3 hours. Depots are release-limited.
How long does Leuprolide stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 15 h for Leuprolide. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Leuprolide reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 12 h to 15 h for Leuprolide.
How reliable is this Leuprolide half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.