Setmelanotide half-life
Setmelanotide has an elimination half-life of about 11 h. Use the free calculator to plot how Setmelanotide levels rise and decay across your own doses.
Open Setmelanotide in the calculator
Reference data
- Half-life
- 11 h
- Route
- SC daily
- Category
- Melanocortins
- Evidence
- Clinical
- Also known as
- Imcivree
FDA label: about 11 hours.
How much Setmelanotide remains over time
For a single dose with first-order elimination, half of what remains is cleared every 11 h.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 11 h | 50% | 50% |
| 2 | 22 h | 25% | 75% |
| 3 | 33 h | 12.5% | 87.5% |
| 4 | 44 h | 6.25% | 93.75% |
| 5 | 2.3 days | 3.13% | 96.88% |
Setmelanotide FAQ
What is the half-life of Setmelanotide?
Setmelanotide has an elimination half-life of about 11 h (SC daily). FDA label: about 11 hours.
How long does Setmelanotide stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 2.3 days for Setmelanotide. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Setmelanotide reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 44 h to 2.3 days for Setmelanotide.
How reliable is this Setmelanotide half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.