Melanotan I half-life
Melanotan I has an elimination half-life of about 1.2 h (range 48 min–1.7 h). Use the free calculator to plot how Melanotan I levels rise and decay across your own doses.
Open Melanotan I in the calculator
Reference data
- Half-life
- 1.2 h (range 48 min–1.7 h)
- Route
- SC / implant
- Category
- Melanocortins
- Evidence
- Limited
- Also known as
- Afamelanotide, MT-I, Scenesse
Small human SC study: 0.8–1.7 hours. The implant formulation is release-limited.
How much Melanotan I remains over time
For a single dose with first-order elimination, half of what remains is cleared every 1.2 h.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 1.2 h | 50% | 50% |
| 2 | 2.4 h | 25% | 75% |
| 3 | 3.6 h | 12.5% | 87.5% |
| 4 | 4.8 h | 6.25% | 93.75% |
| 5 | 6 h | 3.13% | 96.88% |
Melanotan I FAQ
What is the half-life of Melanotan I?
Melanotan I has an elimination half-life of about 1.2 h (range 48 min–1.7 h) (SC / implant). Small human SC study: 0.8–1.7 hours. The implant formulation is release-limited.
How long does Melanotan I stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 6 h for Melanotan I. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Melanotan I reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 4.8 h to 6 h for Melanotan I.
How reliable is this Melanotan I half-life?
Evidence level: Limited. Based on early-phase human trials, small human studies, or animal pharmacokinetics only.