Elamipretide half-life
Elamipretide has an elimination half-life of about 1.5 h (range 1–2 h). Use the free calculator to plot how Elamipretide levels rise and decay across your own doses.
Open Elamipretide in the calculator
Reference data
- Half-life
- 1.5 h (range 1–2 h)
- Route
- SC daily
- Category
- Longevity & mitochondrial
- Evidence
- Limited
- Also known as
- SS-31, Forzinity, Bendavia, MTP-131
Label gives Tmax 0.5–1 h and full urinary recovery by 48 h; plasma half-life is about 1–2 h.
How much Elamipretide remains over time
For a single dose with first-order elimination, half of what remains is cleared every 1.5 h.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 1.5 h | 50% | 50% |
| 2 | 3 h | 25% | 75% |
| 3 | 4.5 h | 12.5% | 87.5% |
| 4 | 6 h | 6.25% | 93.75% |
| 5 | 7.5 h | 3.13% | 96.88% |
Elamipretide FAQ
What is the half-life of Elamipretide?
Elamipretide has an elimination half-life of about 1.5 h (range 1–2 h) (SC daily). Label gives Tmax 0.5–1 h and full urinary recovery by 48 h; plasma half-life is about 1–2 h.
How long does Elamipretide stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 7.5 h for Elamipretide. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Elamipretide reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 6 h to 7.5 h for Elamipretide.
How reliable is this Elamipretide half-life?
Evidence level: Limited. Based on early-phase human trials, small human studies, or animal pharmacokinetics only.