MOTS-c vs Elamipretide half-life
MOTS-c has an elimination half-life of about 30 min; Elamipretide has about 1.5 h. Both are mitochondria-related peptides. Elamipretide (SS-31) is a small synthetic peptide that targets cardiolipin in the inner mitochondrial membrane and has been through clinical trials; MOTS-c is a naturally occurring mitochondrial-derived peptide.
Side by side
| MOTS-c | Elamipretide | |
|---|---|---|
| Half-life | 30 min | 1.5 h (range 1–2 h) |
| Route | SC | SC daily |
| Category | Longevity & mitochondrial | Longevity & mitochondrial |
| Evidence | Anecdotal | Limited |
| Remaining after 24 hours | <0.01% | <0.01% |
| Remaining after 7 days | <0.01% | <0.01% |
| ~97% cleared (5 half-lives) | 2.5 h | 7.5 h |
| Steady state (4-5 half-lives) | 2 h to 2.5 h | 6 h to 7.5 h |
Single-dose decay
Share of one dose remaining over time, assuming first-order elimination. Dashed lines mark each half-life.
MOTS-c (t½ 30 min) Elamipretide (t½ 1.5 h)
MOTS-c: No human PK; estimate. Elamipretide: Label gives Tmax 0.5–1 h and full urinary recovery by 48 h; plasma half-life is about 1–2 h.
FAQ
Which lasts longer, MOTS-c or Elamipretide?
Elamipretide lasts longer. Its half-life is about 1.5 h, versus 30 min for MOTS-c, roughly 3 times longer.
How long do MOTS-c and Elamipretide stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives: roughly 2.5 h for MOTS-c and 7.5 h for Elamipretide. Individual clearance varies.
How long until MOTS-c and Elamipretide reach steady state?
With consistent repeated dosing, levels approach steady state after 4 to 5 half-lives: about 2 h to 2.5 h for MOTS-c, and 6 h to 7.5 h for Elamipretide.
How reliable are these half-lives?
MOTS-c: Anecdotal evidence. Elamipretide: Limited evidence. Anecdotal values are community estimates and may be far off.