Kinetic

Epitalon vs MOTS-c half-life

Epitalon has an elimination half-life of about 30 min; MOTS-c has about 30 min. Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied for effects on telomerase; MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA and studied for metabolic effects. Neither has robust human pharmacokinetic data.

Side by side

EpitalonMOTS-c
Half-life30 min30 min
RouteSCSC
CategoryLongevity & mitochondrialLongevity & mitochondrial
EvidenceAnecdotalAnecdotal
Remaining after 24 hours<0.01%<0.01%
Remaining after 7 days<0.01%<0.01%
~97% cleared (5 half-lives)2.5 h2.5 h
Steady state (4-5 half-lives)2 h to 2.5 h2 h to 2.5 h

Single-dose decay

Share of one dose remaining over time, assuming first-order elimination. Dashed lines mark each half-life.

Epitalon vs MOTS-c single-dose decay 0% 25% 50% 75% 100% 0 30 min 1 h 1.5 h 2 h 2.5 h

Epitalon (t½ 30 min) MOTS-c (t½ 30 min)

Epitalon: No human PK; very short in plasma. MOTS-c: No human PK; estimate.

Model Epitalon doses Model MOTS-c doses

FAQ

Which lasts longer, Epitalon or MOTS-c?

Epitalon and MOTS-c have similar half-lives: about 30 min and 30 min.

How long do Epitalon and MOTS-c stay in your system?

With first-order elimination, about 97% of a single dose is cleared after five half-lives: roughly 2.5 h for Epitalon and 2.5 h for MOTS-c. Individual clearance varies.

How long until Epitalon and MOTS-c reach steady state?

With consistent repeated dosing, levels approach steady state after 4 to 5 half-lives: about 2 h to 2.5 h for Epitalon, and 2 h to 2.5 h for MOTS-c.

How reliable are these half-lives?

Epitalon: Anecdotal evidence. MOTS-c: Anecdotal evidence. Anecdotal values are community estimates and may be far off.

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