Macimorelin half-life
Macimorelin has an elimination half-life of about 4.1 h. Use the free calculator to plot how Macimorelin levels rise and decay across your own doses.
Open Macimorelin in the calculator
Reference data
- Half-life
- 4.1 h
- Route
- Oral (diagnostic)
- Category
- GH secretagogues
- Evidence
- Clinical
- Also known as
- Macrilen
FDA label: about 4.1 hours.
How much Macimorelin remains over time
For a single dose with first-order elimination, half of what remains is cleared every 4.1 h.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 4.1 h | 50% | 50% |
| 2 | 8.2 h | 25% | 75% |
| 3 | 12.3 h | 12.5% | 87.5% |
| 4 | 16.4 h | 6.25% | 93.75% |
| 5 | 20.5 h | 3.13% | 96.88% |
Macimorelin FAQ
What is the half-life of Macimorelin?
Macimorelin has an elimination half-life of about 4.1 h (Oral (diagnostic)). FDA label: about 4.1 hours.
How long does Macimorelin stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 20.5 h for Macimorelin. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until Macimorelin reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 16.4 h to 20.5 h for Macimorelin.
How reliable is this Macimorelin half-life?
Evidence level: Clinical. Based on a regulatory label or well-replicated human pharmacokinetic data.