TB-500 vs Thymosin beta-4 half-life
TB-500 has an elimination half-life of about 1.5 h; Thymosin beta-4 has about 1.5 h. Thymosin beta-4 is the full 43-amino-acid natural protein; TB-500 is a short synthetic fragment based on its active region. They are often conflated, but they are different molecules.
Side by side
| TB-500 | Thymosin beta-4 | |
|---|---|---|
| Half-life | 1.5 h | 1.5 h (range 30 min–2.1 h) |
| Route | SC | IV / SC |
| Category | Healing & repair | Healing & repair |
| Evidence | Anecdotal | Limited |
| Remaining after 24 hours | <0.01% | <0.01% |
| Remaining after 7 days | <0.01% | <0.01% |
| ~97% cleared (5 half-lives) | 7.5 h | 7.5 h |
| Steady state (4-5 half-lives) | 6 h to 7.5 h | 6 h to 7.5 h |
Single-dose decay
Share of one dose remaining over time, assuming first-order elimination. Dashed lines mark each half-life.
TB-500 (t½ 1.5 h) Thymosin beta-4 (t½ 1.5 h)
TB-500: Synthetic Tβ4 fragment with no published human PK; uses full-length Tβ4 data. Thymosin beta-4: Phase 1 (IV, recombinant): terminal half-life 0.5–2.1 hours.
FAQ
Which lasts longer, TB-500 or Thymosin beta-4?
TB-500 and Thymosin beta-4 have similar half-lives: about 1.5 h and 1.5 h.
How long do TB-500 and Thymosin beta-4 stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives: roughly 7.5 h for TB-500 and 7.5 h for Thymosin beta-4. Individual clearance varies.
How long until TB-500 and Thymosin beta-4 reach steady state?
With consistent repeated dosing, levels approach steady state after 4 to 5 half-lives: about 6 h to 7.5 h for TB-500, and 6 h to 7.5 h for Thymosin beta-4.
How reliable are these half-lives?
TB-500: Anecdotal evidence. Thymosin beta-4: Limited evidence. Anecdotal values are community estimates and may be far off.