Melanotan II vs Bremelanotide half-life
Melanotan II has an elimination half-life of about 1 h; Bremelanotide has about 2.7 h. Bremelanotide (PT-141) is a metabolite of Melanotan II. It was developed for, and FDA-approved to treat, hypoactive sexual desire disorder in premenopausal women.
Side by side
| Melanotan II | Bremelanotide | |
|---|---|---|
| Half-life | 1 h | 2.7 h |
| Route | SC | SC as needed |
| Category | Melanocortins | Melanocortins |
| Evidence | Limited | Clinical |
| Remaining after 24 hours | <0.01% | 0.21% |
| Remaining after 7 days | <0.01% | <0.01% |
| ~97% cleared (5 half-lives) | 5 h | 13.5 h |
| Steady state (4-5 half-lives) | 4 h to 5 h | 10.8 h to 13.5 h |
Single-dose decay
Share of one dose remaining over time, assuming first-order elimination. Dashed lines mark each half-life.
Melanotan II (t½ 1 h) Bremelanotide (t½ 2.7 h)
Melanotan II: Rodent data only (about 1 hour); no published human PK. Bremelanotide: FDA label: about 2.7 hours.
FAQ
Which lasts longer, Melanotan II or Bremelanotide?
Bremelanotide lasts longer. Its half-life is about 2.7 h, versus 1 h for Melanotan II, roughly 2.7 times longer.
How long do Melanotan II and Bremelanotide stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives: roughly 5 h for Melanotan II and 13.5 h for Bremelanotide. Individual clearance varies.
How long until Melanotan II and Bremelanotide reach steady state?
With consistent repeated dosing, levels approach steady state after 4 to 5 half-lives: about 4 h to 5 h for Melanotan II, and 10.8 h to 13.5 h for Bremelanotide.
How reliable are these half-lives?
Melanotan II: Limited evidence. Bremelanotide: Clinical evidence. Anecdotal values are community estimates and may be far off.