MGF vs PEG-MGF half-life
MGF has an elimination half-life of about 6 min; PEG-MGF has about 2 days. Mechano growth factor (MGF) is an IGF-1 splice variant that is degraded within minutes. Attaching polyethylene glycol (PEGylation) shields it from breakdown and extends its half-life to days.
Side by side
Single-dose decay
Share of one dose remaining over time, assuming first-order elimination. Dashed lines mark each half-life.
MGF (t½ 6 min) PEG-MGF (t½ 2 days)
At this scale MGF clears almost immediately. Zoomed in to its first five half-lives:
MGF (t½ 6 min) PEG-MGF (t½ 2 days)
MGF: No human PK; thought to persist only minutes in circulation. PEG-MGF: No human PK; pegylation is assumed to extend it to days.
FAQ
Which lasts longer, MGF or PEG-MGF?
PEG-MGF lasts longer. Its half-life is about 2 days, versus 6 min for MGF, roughly 480 times longer.
How long do MGF and PEG-MGF stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives: roughly 30 min for MGF and 10 days for PEG-MGF. Individual clearance varies.
How long until MGF and PEG-MGF reach steady state?
With consistent repeated dosing, levels approach steady state after 4 to 5 half-lives: about 24 min to 30 min for MGF, and 8 days to 10 days for PEG-MGF.
How reliable are these half-lives?
MGF: Anecdotal evidence. PEG-MGF: Anecdotal evidence. Anecdotal values are community estimates and may be far off.