VIP half-life
VIP has an elimination half-life of about 2 min. Use the free calculator to plot how VIP levels rise and decay across your own doses.
Reference data
- Half-life
- 2 min
- Route
- IV / intranasal
- Category
- Nootropic & neuro
- Evidence
- Limited
- Also known as
- Vasoactive intestinal peptide, Aviptadil
Human data: about 1–2 minutes in plasma.
How much VIP remains over time
For a single dose with first-order elimination, half of what remains is cleared every 2 min.
| Half-lives | Time after dose | Remaining | Eliminated |
|---|---|---|---|
| 1 | 2 min | 50% | 50% |
| 2 | 4 min | 25% | 75% |
| 3 | 5 min | 12.5% | 87.5% |
| 4 | 7 min | 6.25% | 93.75% |
| 5 | 9 min | 3.13% | 96.88% |
VIP FAQ
What is the half-life of VIP?
VIP has an elimination half-life of about 2 min (IV / intranasal). Human data: about 1–2 minutes in plasma.
How long does VIP stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives, roughly 9 min for VIP. Individual clearance varies with dose, injection site, kidney function and other factors.
How long until VIP reaches steady state?
With consistent repeated dosing, levels approach steady state after about 4 to 5 half-lives, or roughly 7 min to 9 min for VIP.
How reliable is this VIP half-life?
Evidence level: Limited. Based on early-phase human trials, small human studies, or animal pharmacokinetics only.