Kisspeptin-10 vs Kisspeptin-54 half-life
Kisspeptin-10 has an elimination half-life of about 4 min; Kisspeptin-54 has about 28 min. Both come from the same precursor protein and activate the kisspeptin receptor, which sits upstream of GnRH. The longer kisspeptin-54 is cleared more slowly than kisspeptin-10.
Side by side
| Kisspeptin-10 | Kisspeptin-54 | |
|---|---|---|
| Half-life | 4 min | 28 min |
| Route | IV / SC | IV / SC |
| Category | Reproductive & hormonal | Reproductive & hormonal |
| Evidence | Limited | Limited |
| Remaining after 24 hours | <0.01% | <0.01% |
| Remaining after 7 days | <0.01% | <0.01% |
| ~97% cleared (5 half-lives) | 21 min | 2.3 h |
| Steady state (4-5 half-lives) | 17 min to 21 min | 1.9 h to 2.3 h |
Single-dose decay
Share of one dose remaining over time, assuming first-order elimination. Dashed lines mark each half-life.
Kisspeptin-10 (t½ 4 min) Kisspeptin-54 (t½ 28 min)
Kisspeptin-10: Human IV data: about 4 minutes. Kisspeptin-54: Human data: about 28 minutes.
FAQ
Which lasts longer, Kisspeptin-10 or Kisspeptin-54?
Kisspeptin-54 lasts longer. Its half-life is about 28 min, versus 4 min for Kisspeptin-10, roughly 6.7 times longer.
How long do Kisspeptin-10 and Kisspeptin-54 stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives: roughly 21 min for Kisspeptin-10 and 2.3 h for Kisspeptin-54. Individual clearance varies.
How long until Kisspeptin-10 and Kisspeptin-54 reach steady state?
With consistent repeated dosing, levels approach steady state after 4 to 5 half-lives: about 17 min to 21 min for Kisspeptin-10, and 1.9 h to 2.3 h for Kisspeptin-54.
How reliable are these half-lives?
Kisspeptin-10: Limited evidence. Kisspeptin-54: Limited evidence. Anecdotal values are community estimates and may be far off.