IGF-1 LR3 vs IGF-1 DES half-life
IGF-1 LR3 has an elimination half-life of about 25 h; IGF-1 DES has about 30 min. Both are modified IGF-1 analogues with reduced binding to IGF-binding proteins. LR3 adds a 13-amino-acid extension and an arginine substitution that greatly extend its half-life; DES (1-3) lacks the first three amino acids and acts briefly.
Side by side
Single-dose decay
Share of one dose remaining over time, assuming first-order elimination. Dashed lines mark each half-life.
IGF-1 LR3 (t½ 25 h) IGF-1 DES (t½ 30 min)
At this scale IGF-1 DES clears almost immediately. Zoomed in to its first five half-lives:
IGF-1 LR3 (t½ 25 h) IGF-1 DES (t½ 30 min)
IGF-1 LR3: No human PK; commonly cited 20–30 hours from reduced IGFBP binding. IGF-1 DES: No human PK; very short, typically estimated at 20–30 minutes.
FAQ
Which lasts longer, IGF-1 LR3 or IGF-1 DES?
IGF-1 LR3 lasts longer. Its half-life is about 25 h, versus 30 min for IGF-1 DES, roughly 50 times longer.
How long do IGF-1 LR3 and IGF-1 DES stay in your system?
With first-order elimination, about 97% of a single dose is cleared after five half-lives: roughly 5.2 days for IGF-1 LR3 and 2.5 h for IGF-1 DES. Individual clearance varies.
How long until IGF-1 LR3 and IGF-1 DES reach steady state?
With consistent repeated dosing, levels approach steady state after 4 to 5 half-lives: about 4.2 days to 5.2 days for IGF-1 LR3, and 2 h to 2.5 h for IGF-1 DES.
How reliable are these half-lives?
IGF-1 LR3: Anecdotal evidence. IGF-1 DES: Anecdotal evidence. Anecdotal values are community estimates and may be far off.